Diazepam buccal film for the treatment of acute seizures

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A Comparison of Buccal Midazolam and Intravenous Diazepam for the Acute Treatment of Seizures in Children

OBJECTIVE The purpose of the present study is to compare efficacy and safety of buccal midazolam with intravenous diazepam in control of seizures in Iranian children. METHODS This is a randomized clinical trial. 92 patients with acute seizures, ranging from 6 months to 14 years were randomly assigned to receive either buccal midazolam (32 cases) or intravenous diazepam (60 cases) at the emerg...

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Intranasal midazolam vs rectal diazepam in acute childhood seizures.

One hundred eighty-eight seizure episodes in 46 children were randomly assigned to receive treatment with rectal diazepam and intranasal midazolam with doses of 0.3 mg/kg body weight and 0.2 mg/kg body weight, respectively. Efficacy of the drugs was assessed by drug administration time and seizure cessation time. Heart rate, blood pressure, respiratory rate, and oxygen saturation were measured ...

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Diazepam in the prophylaxis of lignocaine seizures.

Diazepam 0.05-0.25 mg/kg increased the dose of lignocaine required to cause seizures in Rhesus monkeys by 24-34%. Spontaneous ventilation was maintained adequately during lignocaine administration following diazepam treatment and no adverse cardiovascular effects occurred. Before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy. However, prior t...

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Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy.

OBJECTIVE To compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children with epilepsy. DESIGN Prospective randomized study. SETTING Patients' homes and a freestanding children's hospital that serves as a referral center for 5 states. PATIENTS A total of 358 pediatric patients who visited a pediatric ...

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ژورنال

عنوان ژورنال: Epilepsy & Behavior

سال: 2019

ISSN: 1525-5050

DOI: 10.1016/j.yebeh.2019.106537